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1

Scaffold Targeting Drug-Resistant Colon Cancers

Otrubova, Katerina, McGuire, Kathleen L., McAlpine, Shelli R.

Journal:

Journal of Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 593 KB

english, 2007

2

Comprehensive Study of Sansalvamide A Derivatives and their Structure–Activity Relationships against Drug-Resistant Colon Cancer Cell Lines

Otrubova, Katerina, Lushington, Gerald, Vander Velde, David, McGuire, Kathleen L., McAlpine, Shelli R.

Journal:

Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 3.21 MB

english, 2008

3

Binding Studies of Adamantanecarboxylic Acid and a Naphthyl-Bound β-Cyclodextrin by Variable Temperature 1 H NMR

McAlpine, Shelli R., Garcia-Garibay, Miguel A.

Journal:

Journal of Organic Chemistry

Year:

1996

Language:

english

File:

PDF, 159 KB

english, 1996

4

Functionalization of Quinazolin-4-ones Part 3: Synthesis, Structures Elucidation, DNA-PK, PI3K, and Cytotoxicity of Novel 8-Aryl-2-morpholino-quinazolin-4-ones

Heppell, Jacob T., Islam, Md. Amirul, McAlpine, Shelli R., Al-Rawi, Jasim M. A.

Journal:

Journal of Heterocyclic Chemistry

Year:

2018

Language:

english

File:

PDF, 2.81 MB

english, 2018

5

Visualizing Functional Group Distribution in Solid-Support Beads by Using Optical Analysis

Shelli R. McAlpine, Stuart L. Schreiber

Journal:

Chemistry - A European Journal

Year:

1999

Language:

english

File:

PDF, 146 KB

english, 1999

6

Novel antibiotics: C-2 symmetrical macrocycles inhibiting Holliday junction DNA binding by E. coli RuvC

Po-Shen Pan, Fiona A. Curtis, Chris L. Carroll, Irene Medina, Lisa A. Liotta, Gary J. Sharples, Shelli R. McAlpine

Journal:

Bioorganic & Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 878 KB

english, 2006

7

Identification of Sansalvamide a analog potent against pancreatic cancer cell lines

Po-Shen Pan, Kathleen L. McGuire, Shelli R. McAlpine

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 210 KB

english, 2007

8

Understanding Diseases via Receptor Regulation

Shelli R McAlpine

Journal:

Chemistry & Biology

Year:

2004

Language:

english

File:

PDF, 91 KB

english, 2004

9

Synthesis and biological evaluation of histone deacetylase inhibitors that are based on FR235222: A cyclic tetrapeptide scaffold

Erinprit K. Singh, Suchitra Ravula, Chung-Mao Pan, Po-Shen Pan, Robert C. Vasko, Stephanie A. Lapera, Sujith V.W. Weerasinghe, Mary Kay H. Pflum, Shelli R. McAlpine

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 157 KB

english, 2008

10

A progressive synthetic strategy for class B synergimycins

Jennifer L. Robinson, Rachel E. Taylor, Lisa A. Liotta, Megan L. Bolla, Enrique V. Azevedo, Irene Medina, Shelli R. McAlpine

Journal:

Tetrahedron Letters

Year:

2004

Language:

english

File:

PDF, 271 KB

english, 2004

11

Novel antibiotics: second generation macrocyclic peptides designed to trap Holliday junctions

Lisa A. Liotta, Irene Medina, Jennifer L. Robinson, Chris L. Carroll, Po-Shen Pan, Ricardo Corral, Jennifer V.C. Johnston, Kristina M. Cook, Fiona A. Curtis, Gary J. Sharples, Shelli R. McAlpine

Journal:

Tetrahedron Letters

Year:

2004

Language:

english

File:

PDF, 345 KB

english, 2004

12

High-yielding macrocyclization conditions used in the synthesis of novel Sansalvamide A derivatives

Thomas J. Styers, Rodrigo Rodriguez, Po-Shen Pan, Shelli R. McAlpine

Journal:

Tetrahedron Letters

Year:

2006

Language:

english

File:

PDF, 112 KB

english, 2006

13

Histone deacetylase inhibitors: synthesis of cyclic tetrapeptides and their triazole analogs

Erinprit K. Singh, Lidia A. Nazarova, Stephanie A. Lapera, Leslie D. Alexander, Shelli R. McAlpine

Journal:

Tetrahedron Letters

Year:

2010

Language:

english

File:

PDF, 667 KB

english, 2010

14

C32-O-imidazol-2-yl-methyl ether derivatives of the immunosuppressant ascomycin with improved therapeutic potential

Mark T. Goulet, Shelli R. McAlpine, Mary Jo Staruch, Samuel Koprak, Francis J. Dumont, John G. Cryan, Gregory J. Wiederrecht, Raymond Rosa, Mary Beth Wilusz, Laurence B. Peterson, Matthew J. Wyvratt,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 381 KB

english, 1998

15

A comprehensive study of Sansalvamide A derivatives: The structure–activity relationships of 78 derivatives in two pancreatic cancer cell lines

Po-Shen Pan, Robert C. Vasko, Stephanie A. Lapera, Victoria A. Johnson, Robert P. Sellers, Chun-Chieh Lin, Chung-Mao Pan, Melinda R. Davis, Veronica C. Ardi, Shelli R. McAlpine

Journal:

Bioorganic & Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 1.62 MB

english, 2009

16

Synthesis and evaluation of biotinylated sansalvamide A analogs and their modulation of Hsp90

Joseph B. Kunicki, Mark N. Petersen, Leslie D. Alexander, Veronica C. Ardi, Jeanette R. McConnell, Shelli R. McAlpine

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 588 KB

english, 2011

17

A small molecule that preferentially binds the closed conformation of Hsp90

Leslie D. Alexander, James R. Partridge, David A. Agard, Shelli R. McAlpine

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 585 KB

english, 2011

18

An Hsp90 modulator that exhibits a unique mechanistic profile

Deborah M. Ramsey, Jeanette R. McConnell, Leslie D. Alexander, Kaishin W. Tanaka, Chester M. Vera, Shelli R. McAlpine

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 483 KB

english, 2012

19

Synthesis of sansalvamide A peptidomimetics: triazole, oxazole, thiazole, and pseudoproline containing compounds

Melinda R. Davis, Erinprit K. Singh, Hendra Wahyudi, Leslie D. Alexander, Joseph B. Kunicki, Lidia A. Nazarova, Kelly A. Fairweather, Andrew M. Giltrap, Katrina A. Jolliffe, Shelli R. McAlpine

Journal:

Year:

2012

Language:

english

File:

PDF, 1.20 MB

english, 2012

20

Progress toward the synthesis of Urukthapelstatin A and two analogues

Chung-Mao Pan, Chun-Chieh Lin, Seong Jong Kim, Robert P. Sellers, Shelli R. McAlpine

Journal:

Tetrahedron Letters

Year:

2012

Language:

english

File:

PDF, 474 KB

english, 2012

21

Solid Phase Versus Solution Phase Synthesis of Heterocyclic Macrocycles

Kim, Seong, McAlpine, Shelli

Journal:

Year:

2013

Language:

english

File:

PDF, 371 KB

english, 2013

22

Total Synthesis and Biological Activity of Natural Product Urukthapelstatin A

Lin, Chun-Chieh, Tantisantisom, Worawan, McAlpine, Shelli R.

Journal:

Organic Letters

Year:

2013

Language:

english

File:

PDF, 543 KB

english, 2013

23

Heat shock proteins 27, 40, and 70 as combinational and dual therapeutic cancer targets

McConnell, Jeanette R., McAlpine, Shelli R.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 457 KB

english, 2013

24

Synthesis, Structure–Activity Analysis, and Biological Evaluation of Sanguinamide B Analogues

Wahyudi, Hendra, Tantisantisom, Worawan, Liu, Xuechao, Ramsey, Deborah M., Singh, Erinprit K., McAlpine, Shelli R.

Journal:

Journal of Organic Chemistry

Year:

2012

Language:

english

File:

PDF, 2.60 MB

english, 2012

25

Total Synthesis of trans , trans- Sanguinamide B and Conformational Isomers

Singh, Erinprit K., Ramsey, Deborah M., McAlpine, Shelli R.

Journal:

Organic Letters

Year:

2012

Language:

english

File:

PDF, 615 KB

english, 2012

26

Psammaplysin F: A unique inhibitor of bacterial chromosomal partitioning

Ramsey, Deborah M., Amirul Islam, Md., Turnbull, Lynne, Davis, Rohan A., Whitchurch, Cynthia B., McAlpine, Shelli R.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 538 KB

english, 2013

27

Halting metastasis through CXCR4 inhibition

Ramsey, Deborah M., McAlpine, Shelli R.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 619 KB

english, 2013

28

Effectively Delivering a Unique Hsp90 Inhibitor Using Star Polymers

Kim, Seong Jong, Ramsey, Deborah M., Boyer, Cyrille, Davis, Thomas P., McAlpine, Shelli R.

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 359 KB

english, 2013

29

Mechanistic Studies of Sansalvamide A-Amide: An Allosteric Modulator of Hsp90

Vasko, Robert C., Rodriguez, Rodrigo A., Cunningham, Christian N., Ardi, Veronica C., Agard, David A., McAlpine, Shelli R.

Journal:

ACS Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 1.86 MB

english, 2010

30

Mechanistic Studies of Sanguinamide B Derivatives: A Unique Inhibitor of Eukaryotic Ribosomes

Tantisantisom, Worawan, Ramsey, Deborah M., McAlpine, Shelli R.

Journal:

Organic Letters

Year:

2013

Language:

english

File:

PDF, 1.54 MB

english, 2013

31

A heat shock protein 90 inhibitor that modulates the immunophilins and regulates hormone receptors without inducing the heat shock response

McConnell, Jeanette R., Alexander, Leslie A., McAlpine, Shelli R.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 889 KB

english, 2014

32

Sanguinamide B analogs: identification of active macrocyclic structures

Wahyudi, Hendra, Tantisantisom, Worawan, McAlpine, Shelli R.

Journal:

Tetrahedron Letters

Year:

2014

Language:

english

File:

PDF, 925 KB

english, 2014

33

A potential rhodium cancer therapy: Studies of a cytotoxic organorhodium(I) complex that binds DNA

McConnell, Jeanette R., Rananaware, Dimple P, Ramsey, Deborah M., Buys, Kai N., Cole, Marcus L., McAlpine, Shelli R.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 561 KB

english, 2013

34

Novel Antibiotics: Macrocyclic Peptides Designed to Trap Holliday Junctions

Bolla, Megan L., Azevedo, Enrique V., Smith, Jason M., Taylor, Rachel E., Ranjit, Dev K., Segall, Anca M., McAlpine, Shelli R.

Journal:

Organic Letters

Year:

2003

Language:

english

File:

PDF, 147 KB

english, 2003

35

Evaluation of Di-Sansalvamide A Derivatives: Synthesis, Structure−Activity Relationship, and Mechanism of Action

Alexander, Leslie D., Sellers, Robert P., Davis, Melinda R., Ardi, Veronica C., Johnson, Victoria A., Vasko, Robert C., McAlpine, Shelli R.

Journal:

Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 1.72 MB

english, 2009

36

Determination of Functional Group Distribution within Rasta Resins Utilizing Optical Analysis

McAlpine, Shelli R., Lindsley, Craig W., Hodges, John C., Leonard, Daniele M., Filzen, G. Fredrick

Journal:

Journal of Combinatorial Chemistry

Year:

2001

Language:

english

File:

PDF, 495 KB

english, 2001

37

Synthesis and Cytotoxicity of a New Class of Potent Decapeptide Macrocycles

Davis, Melinda R., Styers, Thomas J., Rodriguez, Rodrigo A., Pan, Po-Shen, Vasko, Robert C., McAlpine, Shelli R.

Journal:

Organic Letters

Year:

2008

Language:

english

File:

PDF, 156 KB

english, 2008

38

Studies of Naphthyl-Substituted β-Cyclodextrins. Self-Aggregation and Inclusion of External Guests

McAlpine, Shelli R., Garcia-Garibay, Miguel A.

Journal:

Journal of the American Chemical Society

Year:

1998

Language:

english

File:

PDF, 102 KB

english, 1998

39

Macrocycles That Inhibit the Binding between Heat Shock Protein 90 and TPR-Containing Proteins

Ardi, Veronica C., Alexander, Leslie D., Johnson, Victoria A., McAlpine, Shelli R.

Journal:

ACS Chemical Biology

Year:

2011

Language:

english

File:

PDF, 3.38 MB

english, 2011

40

Inside−Outside Isomerism of β-Cyclodextrin Covalently Linked with a Naphthyl Group

McAlpine, Shelli R., Garcia-Garibay, Miguel A.

Journal:

Journal of the American Chemical Society

Year:

1996

Language:

english

File:

PDF, 167 KB

english, 1996

41

Synthesis and Cytotoxicity of Novel Sansalvamide A Derivatives

Carroll, Chris L., Johnston, Jennifer V. C., Kekec, Ahmet, Brown, Joseph D., Parry, Emily, Cajica, Julia, Medina, Irene, Cook, Kristina M., Corral, Ricardo, Pan, Po-Shen, McAlpine, Shelli R.

Journal:

Organic Letters

Year:

2005

Language:

english

File:

PDF, 6 KB

english, 2005

42

Chemically Accessible Hsp90 Inhibitor That Does Not Induce a Heat Shock Response

Koay, Yen Chin, McConnell, Jeanette R., Wang, Yao, Kim, Seong Jong, Buckton, Laura K., Mansour, Flora, McAlpine, Shelli R.

Journal:

ACS Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 1.86 MB

english, 2014

43

Synthesis and Cytotoxicity of Novel Sansalvamide A Derivatives

Carroll, Chris L., Johnston, Jennifer V. C., Kekec, Ahmet, Brown, Joseph D., Parry, Emily, Cajica, Julia, Medina, Irene, Cook, Kristina M., Corral, Ricardo, Pan, Po-Shen, McAlpine, Shelli R.

Journal:

Organic Letters

Year:

2005

Language:

english

File:

PDF, 96 KB

english, 2005

44

Synthesis and novel structure–activity relationships of potent sansalvamide A derivatives

Otrubova, Katerina, Styers, Thomas J., Pan, Po-Shen, Rodriguez, Rodrigo, McGuire, Kathleen L., McAlpine, Shelli R.

Journal:

Chemical Communications

Year:

2006

Language:

english

File:

PDF, 244 KB

english, 2006

45

Design, synthesis and anticancer mechanistic studies of linked azoles

Islam, Md. Amirul, Zhang, Yuqi, Wang, Yao, McAlpine, Shelli R.

Journal:

Year:

2015

Language:

english

File:

PDF, 725 KB

english, 2015

46

Synthesis of macrocycles that inhibit protein synthesis: stereochemistry and structural based studies on sanguinamide B derivatives

Pietkiewicz, Adrian L., Wahyudi, Hendra, McConnell, Jeanette R., McAlpine, Shelli R.

Journal:

Tetrahedron Letters

Year:

2014

Language:

english

File:

PDF, 867 KB

english, 2014

47

The fungal natural product (1S,3S)-austrocortirubin induces DNA damage in HCT116 cells via a mechanism unique from other DNA damaging agents

Wang, Yao, Islam, Md. Amirul, Davis, Rohan A., McAlpine, Shelli R.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 763 KB

english, 2015

48

Heat-shock protein 90 inhibitors: will they ever succeed as chemotherapeutics?

Wang, Yao, McAlpine, Shelli R

Journal:

Future Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 1.56 MB

english, 2015

49

Predicting the unpredictable: Recent structure–activity studies on peptide-based macrocycles

Wahyudi, Hendra, McAlpine, Shelli R.

Journal:

Bioorganic Chemistry

Year:

2015

Language:

english

File:

PDF, 3.28 MB

english, 2015

50

Thioimidazoline based compounds reverse glucocorticoid resistance in human acute lymphoblastic leukemia xenografts

Toscan, Cara E., Rahimi, Marwa, Bhadbhade, Mohan, Pickford, Russell, McAlpine, Shelli R., Lock, Richard B.

Journal:

Organic & Biomolecular Chemistry

Year:

2015

Language:

english

File:

PDF, 1000 KB

english, 2015

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